Immunohistochemistry of bone marrow sections showed that megakaryocytes express cox-1 (fig. The n and c termini to the intermembrane space. Note: mouseover a species abbreviation on the product page to display the fullname. These findings underline the presence of cox20 in several distinct protein complexes. Cells harvested at day +16, when both isoforms are observed, were treated with the following: (. Quite unexpectedly, megakaryocytes stained positively also for cox-2 (fig.
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Mature human cox 2. This fact is indicative of an additional function. 5-asa inhibits cox activity, and serum and mucosal pg levels decline after 5-asa treatment (. We speculated that mba1 is required for the efficient transfer of pcox2 to cox20. An increase in yellow fluorescence induced by increased mitochondrial membrane potential was observed when the cells were incubated with 30 mmol/l glucose compared with 5.
In agreement with previously published findings, mitochondria from. However, it remains unclear how ros from the mitochondrial electron transport chain could contribute to the progression of diabetic microvascular complications, including nephropathy, retinopathy, and neuropathy. In contrast, the association of cox20 with mature cox2 is mba1 independent.